Top abstracts from ICLE 2018 will be published in
Human Gene Therapy
(Impact Factor 4.187)
Special Issue: Immune Gene Therapy
Guest Editor: Adi Barzel, PhD (Chair ICLE 2018, Tel Aviv University)
Great strides have been made in recent years in the engineering of immune cells for cancer immunotherapy. In particular, the engineering of T cells to express chimeric antigen receptors (CARs) directed against CD19 has led to remarkable rates of complete remissions (CRs) in different hematological malignancies and subsequent breakthrough FDA approvals of two CAR-T products. However, many challenges remain. Treatment is cumbersome, expensive, and difficult to scale up. Response to treatment is associated with a high risk for severe side effects and a significant proportion of patients relapse. In addition, the application of T cell engineering for the treatment of solid tumors is complicated by the paucity of well-characterized tumor specific antigens and by the immunosuppressive tumor microenvironment.
The emerging field of immune gene therapy aims to tackle these challenges by employing cutting-edge technologies of viral and nonviral vectorology, genome editing and protein design, as well as advanced clinical protocols for adoptive T cell therapies and immune modulation. Immune gene therapy may be applied for the treatment or prevention not only of cancer, but also autoimmune diseases, pathogenic infections, and primary immunodeficiencies. Realizing the full promise of immune gene therapy will thus require the combined efforts of a dedicated community. Human Gene Therapy aims to contribute to this task by publishing a special issue.
The Human Gene Therapy special issue on “Immune Gene Therapy” aims to provide a collection of manuscripts in the following general categories:
Clinical updates in immune gene therapy of hematological malignancies
Fighting solid tumors with engineered lymphocytes
Nonviral vectors and transposons for immune gene therapy
Genome editing in lymphocytes
Allogenic therapy with engineered lymphocytes
Engineering lymphocytes to prevent or clear infections
Immune gene therapy for autoimmune diseases
Safety switches and controlled expression in inmune gene therapy
About Human Gene Therapy
Human Gene Therapy is the premier, multidisciplinary journal covering all aspects of gene therapy. The Journal publishes in-depth coverage of DNA, RNA, and cell therapies by delivering the latest breakthroughs in research and technologies. Human Gene Therapy provides a central forum for scientific and clinical information, including ethical, legal, regulatory, social, and commercial issues, which enables the advancement and progress of therapeutic procedures leading to improved patient outcomes, and ultimately, to curing diseases.
Latest Impact Factor* is 4.187 *2016 Journal Citation Reports® (Clarivate Analytics, 2017)
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