LMU involved in a new Collaborative Research Center
The Deutsche Forschungsgemeinschaft has approved funding for a new CRC on immunotherapy, while a second large-scale project has been extended.
The new transregional Collaborative Research Center (CRC) – TRR-338 LETSIMMUN (which stands for Lymphocyte Engineering for Therapeutic Synthetic Immunity) – will be based in Munich and Würzburg.
The new CRC, in which LMU researchers will play a significant role, is intended to develop new concepts in the field of adoptive T-cell therapy, with the aim of modifying the function of immune cells so as to confer therapeutic synthetic immunity on patients. The basic idea is to genetically alter lymphocytes in ways that enable them to activate the body’s own immune defenses in a precisely regulatable manner.
The scientists involved in the project plan to utilize a variety of lymphocyte-engineering technologies to optimize the structures of specific receptors on T-cells, and control their expression in an intentional temporal fashion. In addition, various regulatory and fail-safe mechanisms will be incorporated into these synthetic T-cells, in order to ensure that they are resistant to suppression and that their activities can be closely and safely monitored.
Source: www.lmu.de. (n.d.). LMU involved in a new Collaborative Research Center. [online]
T-cells will be genetically modified for a new kind of immunotherapy. | © IMAGO / Science Photo Library
The DFG Collaborative Research Centers are among the most important research funding programs in Germany. They support complex, interdisciplinary and long-term research initiatives. They are initially approved for four years and can receive funding for up to 12 years. A TRR (or “transregio”) is a CRC with partners cooperating on a trans-regional basis. Source:www.ch.tum.de. (n.d.). CRCs to study immunotherapies and photocatalysis – Fakultät für Chemie. [online]
TRR 325: Assembly Controlled Chemical Photocatalysis
The basic substances used in many everyday materials are produced with the aid of catalysts. Photocatalysis opens up the way to new approaches and products that would be virtually impossible with conventional processes. The goal of the TRR “Controlling chemical photocatalysis through molecular assemblies” is to develop a new generation of photocatalytic systems for organic synthesis by controlling interactions between catalysts and reactive partners. The long-term objective is to help conserve more energy and resources in light-driven reactions. The speaker is Thorsten Bach, a professor of organic chemistry at TUM. The University of Regensburg is a co-applicant. Source: www.ch.tum.de. (n.d.). CRCs to study immunotherapies and photocatalysis – Fakultät für Chemie. [online]
TRR 338: LETSIMMUN
ymphocytes are a subgroup of the white blood cells. They include the T cells, for example. The TRR “LETSIMMUN – Lymphocyte Engineering for Therapeutic Synthetic Immunity” will investigate – among other questions – how genetically engineered lymphocytes might be used to fight infections, tumors or autoimmune diseases. The group wishes to help establish immunotherapies with modified lymphocytes as a medically safe and effective treatment for as many patients as possible. The speaker is Dirk Busch, Professor of Medical Microbiology, Immunology and Hygiene. Co-applicants are the LMU München and the University of Würzburg. Source: www.ch.tum.de. (n.d.). CRCs to study immunotherapies and photocatalysis – Fakultät für Chemie. [online]
TRR 326: Geometry and Arithmetic of Uniformized Structures (GAUS)
The CRC “Geometry and Arithmetic of Uniformized Structures (GAUS)” will work in the field of theoretical mathematics. The basic idea behind uniformization is to replace complicated geometric objects through simpler ones without changing the local structure. By translating the complexity into another “language”, the group wishes to open up new perspectives on the original objects and make them accessible for central geometric and arithmetic problems. Applicant universities are Frankfurt/Main, Darmstadt and Heidelberg. TUM is represented by Eva Viehmann, Professor of Arithmetic Geometry. Source: www.ch.tum.de. (n.d.). CRCs to study immunotherapies and photocatalysis – Fakultät für Chemie. [online]